Immunogenetics

Hematopoietic stem cell transplantation (HSCT) or bone marrow transplantation is a medical procedure in the field of hematology and oncology that involves transplantation of hematopoietic stem cells (HSC). It is most often performed for people with diseases of the blood or bone marrow, or certain types of cancer (e.g. leukemia). In the most cases of so‑called allogeneic HSCT, patients don’t find suitable donor in their family, so physicians must search unrelated donors in international registries of stem cells donors.

Selection of potential donor is complicated process that often takes more than one year and sometimes, unfortunately, with no success. It means there is no suitable donor for a particular patient with a reasonable level of risk. The selection process contains several steps, such donor reservation, donor medical test requests, blood sample request, confirmation genetic (HLA) typing, confirmation of donor willingness, transplantation schedule, etc.

The goal of this project is to better understand HLA system, improve selection and transplantation process of unrelated stem cell donors and effectiveness of registries by new ICT technologies.

Genetic comparison of populations

HLA Explorer

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